Impact of Vigorous Exercise on Blood Serum Creatinine Concentration Among Students Athletes

Impact of Vigorous Exercise on Blood Serum Creatinine


  • Moheb Ullah Department of Education Sciences, National University of Modern Language (NUML), Islamabad, Pakistan
  • Alamgir Khan Department of Sports Sciences & Physical Education, University of the Punjab, Lahore, Pakistan
  • Muhammad Jamil
  • Muhammad Zafar Iqbal Butt Department of Sports Sciences & Physical Education, University of the Punjab, Lahore, Pakistan
  • Imran Ullah Department of Sports Sciences & Physical Education, Sarhad University of Science & Information Technology, Peshawar, Pakistan
  • Muhammad Zubair Department of Sports Sciences & Physical Education, Gomal University, Dera Ismail Khan, Pakistan
  • Salman Saheem Department of Sports Sciences & Physical Education, Gomal University, Dera Ismail Khan, Pakistan
  • Hamza Nasir Center of Physical Education, Health & Support Sciences, University of Sindh, Jamshoro, Pakistan



Vigorous, Exercise, Serum Creatinine, Students


Creatinine is a chemical compound left over from energy-producing processes in your Healthy kidneys that filter creatinine out of the blood. Creatinine exits your body as a waste product in urine. Objective: To examine the impact of vigorous-intensity exercises on serum creatinine concentration among student athletes. Methods: Participants were categorized as the control group (CG=n-15) and the experimental group (EG=n-15). Eight-week self-made vigorous intensity exercise protocol was applied on EG. 5 ml blood was collected from each subject, and similarly, serum creatinine concentration was assessed through a serum creatinine test in a biochemistry laboratory. The results (pre and post-test) were statistically tested by independent t-test, mean, and paired sample t-test as statistical tools. Results: A statistically significant difference was found in the Creatinine level between the pretest and posttest scores of EG (P < 0.05) after the treatment. No significant difference was observed in Creatinine level in CG's pretest and posttest scores (P > 0.05). Conclusions: The study shows a considerable difference in the pre and post-test of the subjects of CG and EG, and thus it is shown that vigorous exercise has a positive impact on kidney functions, particularly on creatinine


Tonello L, Reichert FF, Oliveira-Silva I, Del Rosso S, Leicht AS, Boullosa DA. Correlates of heart rate measures with incidental physical activity and cardiorespiratory fitness in overweight female workers. Frontiers in Physiology. 2016 Jan; 6: 405. doi: 10.3389/fphys.2015.00405.

Wilson PW, Paffenbarger Jr RS, Morris JN, Havlik RJ. Assessment methods for physical activity and physical fitness in population studies: report of a NHLBI workshop. American Heart Journal. 1986 Jun; 111(6): 1177-92. doi: 10.1016/0002-8703(86)90022-0.

Allison SE. Self-care requirements for activity and rest: An Orem nursing focus. Nursing Science Quarterly. 2007 Jan; 20(1): 68-76. doi: 10.1177/0894318406296297.

Amutha JJ. Lupus Nephritis. International Journal of Advances in Nursing Management. 2017 Jun; 5(2): 169-71. doi: 10.5958/2454-2652.2017.00036.1.

Bourey PA. Renal Disorders. Radiologic Technology. 2008 May; 79(5): 433-46.

Ridley JW. Metabolic origins of urine and other body fluids. In: Ridley JW, editors. Fundamentals of the Study of Urine and Body Fluids. Springer; 2018: 45-60. doi: 10.1007/978-3-319-78417-5_4.

Wallace MA. Anatomy and physiology of the kidney. AORN Journal. 1998 Nov; 68(5): 799-820. doi: 10.1016/S0001-2092(06)62377-6.

Azar AT, editor. Modelling and Control of Dialysis Systems: Volume 1: Modeling Techniques of Hemodialysis Systems. Springer; 2012. doi: 10.1007/978-3-642-27458-9.

McLafferty E, Johnstone C, Hendry C, Farley A. The urinary system. Nursing Standard. 2014 Mar; 28(27): 43-50. doi: 10.7748/ns2014.

Eaton DC and Pooler JP. Vander's renal physiology. Mc Graw Hil Medicall; 2009.

Metheny N. Fluid and electrolyte balance. Jones & Bartlett Publishers; 2012.

Brosnan JT and Brosnan ME. Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annual Reviews in Nutrition. 2007 Aug; 27: 241-61. doi: 10.1146/annurev.nutr.27.061406.093621.

Passwater RA. Creatine. McGraw-Hill Companies; 1995.

Wallimann T, Tokarska-Schlattner M, Schlattner U. The creatine kinase system and pleiotropic effects of creatine. Amino Acids. 2011 May; 40: 1271-96. doi: 10.1007/s00726-011-0877-3.

Wyss M and Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiological Reviews. 2000 Jul; 80(3): 1107-213. doi: 10.1152/physrev.2000.80.3.1107.

Khani M. Simulation of Physiological Function of the Kidney in Filtering Blood Sodium Parameter by Micro and Nano Technologies: A Review. International Journal of Science and Engineering Investigations. 2015 Jul; 42(4): 40-50.

Calles-Escandon J, Cunningham JJ, Snyder P, Jacob R, Huszar G, Loke J, et al. Influence of exercise on urea, creatinine, and 3-methylhistidine excretion in normal human subjects. American Journal of Physiology-Endocrinology and Metabolism. 1984 Apr; 246(4): E334-8. doi: 10.1152/ajpendo.1984.246.4.E334.

Ishikawa Y, Gohda T, Tanimoto M, Omote K, Furukawa M, Yamaguchi S, et al. Effect of exercise on kidney function, oxidative stress, and inflammation in type 2 diabetic KK-Ay mice. Experimental Diabetes Research. 2012 Oct; 2012: 702948. doi: 10.1155/2012/702948.

Blood Pressure Lowering Treatment Trialists’ Collaboration. Blood pressure lowering and major cardiovascular events in people with and without chronic kidney disease: meta-analysis of randomised controlled trials. BMJ. 2013 Oct; 347: 1-15. doi: 10.1136/bmj.f5680.

Pandya D, Nagrajappa AK, Ravi KS. Assessment and correlation of urea and creatinine levels in saliva and serum of patients with chronic kidney disease, diabetes and hypertension–a research study. Journal of Clinical and Diagnostic Research: JCDR. 2016 Oct; 10(10): ZC58. doi: 10.7860/JCDR/2016/20294.8651.

Sikiru L and Okoye GC. Therapeutic effect of continuous exercise training program on serum creatinine concentration in men with hypertension: a randomized controlled trial. Ghana Medical Journal. 2014 Sep; 48(3): 135-42. doi: 10.4314/gmj.v48i3.3.

Johansen KL and Painter P. Exercise in individuals with CKD. American Journal of Kidney Diseases. 2012 Jan; 59(1): 126-34. doi: 10.1053/j.ajkd.2011.10.008



DOI: 10.54393/tt.v4i02.107
Published: 2023-06-30

How to Cite

Ullah, M. ., Khan, A. ., Jamil, M. ., Iqbal Butt, M. Z. ., Ullah, I. ., Zubair, M. ., Saheem, S. ., & Nasir, H. . (2023). Impact of Vigorous Exercise on Blood Serum Creatinine Concentration Among Students Athletes: Impact of Vigorous Exercise on Blood Serum Creatinine. THE THERAPIST (Journal of Therapies &Amp; Rehabilitation Sciences), 4(02), 33–36.



Original Article